… verapamil, digoxin, and amiodarone. In this review, Pgp-mediated DDIs and their effects
on … renal clearance of quinidine at elevated doses, although digoxin’s effect on the AUC of …

… Digoxin verapamil and quinidine are substrates of P-glycoprotein and verapamil and quinidine
inhibit the clearance of digoxin … amiodarone combined with digoxin increases the digoxin …

… for arrhythmias associated with digitalis toxicity, excess … action is very similar to that of
quinidine, but it does not prolong … organ system, amiodarone treatment should be reevaluated …

… Verapamil also interacts with digoxin and may produce a … Administration of quinidine to a
patient already on digoxin leads to an … These include verapamil, amiodarone, propafenone and …

… intoxication decreases by selecting the dose of digoxin based on blood digoxin concentrations.
As class I antiarrhythmic drugs and amiodarone cause ADRs more commonly at higher …

… digoxin when quinidine is coadministered reflects this action in vivo, particularly since the
effects of quinidine (increased digoxin … digoxin concentrations (eg, amiodarone, verapamil, …

… [1,2] Digoxin is the only available preparation of digitalis in the United States. Cardiac … who
have conditions which may alter their sensitivity to digoxin. Quinidine, verapamil, amiodarone, …

… Our intention is not … effects with their action depending on the route of administration, plasma
levels, and active metabolites. Such examples are propafenone, quinidine, and amiodarone…

… require monitoring closely to avoid digitalis toxicity. Amiodarone, verapamil, quinidine, and
diltiazem increase the serum levels of digoxin and can lead to toxicity. The recommendation …

… transporters (eg, amiodarone and verapamil) can increase serum digoxin levels. Inducers of
… The Class IA antiarrhythmic, quinidine, competes with digoxin for binding sites and inhibits …